ABSTRACT

The aim of the present study was to evaluate the anti-allergic effect of apple condensed tannins (ACT) in patients with atopic dermatitis (AD) as a pilot study. An ACT supplement given to the patients at oral doses of 10 mg/kg per day for 8 weeks reduced the inflammation, lichenification, cracking, itching, sleep dis- turbance and peripheral blood eosinophil counts. Itching and sleep disturbance scores after ACT supplement even for 2 weeks were significantly decreased compared with the control group. The results suggest that ACT has an anti-allergic effect and that its use improved the symptoms of AD.

KEY WORDS:
anti-allergic effect, apple polyphenol, atopic dermatitis

Received: 10 June 1999.
Accepted: 1 November 1999.

Allergology International 2000; 1: 69-73

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